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Week Mon. 11 Tue. 12 Wed. 13 List

	Mon. 11	Tue. 12	Wed. 13
09:00 10:00 11:00 12:00 13:00 14:00 15:00 16:00 17:00 18:00	SESSION 1: PHILOSOPHIE OF SCIENCE AND HETEROGENEITY From variation to variability and back: the many-faces of heterogeneity in biology. Questioning the interplay between genetic, epigenetic and gene expression variability from microbial to cancer cells Round table 13:30 - 15:30 (2h) SESSION 1: PHILOSOPHIE OF SCIENCE AND HETEROGENEITY Auditorium CBI 13:30 - 14:30 (1h) From variation to variability and back: the many-faces of heterogeneity in biology. Francesca Merlin 14:30 - 15:00 (30min) Questioning the interplay between genetic, epigenetic and gene expression variability from microbial to cancer cells Jean-Pascal Capp 15:00 - 15:30 (30min) Round table Marie-Christine Miquel, Jean-Pascal Capp & Francesca Merlin Coffee break 15:30 - 16:15 (45min) Coffee break SESSION 2: NETWORKS: AN APPROACH TO COMPLEX SYSTEMS AND HETEROGENEOUS SYSTEMS Heterogeneity, networks and epidemics Interaction network dynamics in Drosophila Phenotypic variability, plasticity and 3D genome structure 16:15 - 18:15 (2h) SESSION 2: NETWORKS: AN APPROACH TO COMPLEX SYSTEMS AND HETEROGENEOUS SYSTEMS Auditorium CBI 16:15 - 17:15 (1h) Heterogeneity, networks and epidemics Bertrand Jouve 17:15 - 17:45 (30min) Interaction network dynamics in Drosophila Cristian Pasquaretta 17:45 - 18:15 (30min) Phenotypic variability, plasticity and 3D genome structure Vera Pancaldi	SESSION 3: HETEROGENEITY IN MORPHOGENESIS To stay or leave? Cell-to-cell heterogeneity and progenitor’s segregation within the bird embryonic tail. Progenitor behaviour shapes olfactory sensory organ in zebrafish Coffee break Modeling the molecular clock controlling neurogenesis Dynamic changes in the Drosophila hematopoietic niche induced by immune stress 9:00 - 12:15 (3h15) SESSION 3: HETEROGENEITY IN MORPHOGENESIS Auditorium CBI 9:00 - 10:00 (1h) To stay or leave? Cell-to-cell heterogeneity and progenitor’s segregation within the bird embryonic tail. Auditorium CBI Bertrand Benazeraf 10:00 - 10:30 (30min) Progenitor behaviour shapes olfactory sensory organ in zebrafish Auditorium CBI Marie Zilliox 10:30 - 11:15 (45min) Coffee break 11:15 - 11:45 (30min) Modeling the molecular clock controlling neurogenesis Auditorium CBI Delphine Bretonniere 11:45 - 12:15 (30min) Dynamic changes in the Drosophila hematopoietic niche induced by immune stress Auditorium CBI Ismael Morin-Poulard Lunch 12:15 - 13:30 (1h15) Lunch SESSION 4: HETEROGENEITY IN CANCER AND CHROMATIN A connection between cohesin complex member STAG2, DNA loop extrusion and metastasis in Ewing sarcoma 3D Chromatin compartmentalization leakages and Gene expression variability Mitochondrial dynamics regulates plasticity between proliferative and quiescent states to control stemness properties and leukemia propagation 13:30 - 15:30 (2h) SESSION 4: HETEROGENEITY IN CANCER AND CHROMATIN Auditorium CBI 13:30 - 14:30 (1h) A connection between cohesin complex member STAG2, DNA loop extrusion and metastasis in Ewing sarcoma Olivier Delattre 14:30 - 15:00 (30min) 3D Chromatin compartmentalization leakages and Gene expression variability Olivier Cuvier 15:00 - 15:30 (30min) Mitochondrial dynamics regulates plasticity between proliferative and quiescent states to control stemness properties and leukemia propagation Clément Larrue Coffee break 15:30 - 16:15 (45min) Coffee break SESSION 5: HETEROGENEITY AS AN OPTIMUM Heterogeneity in gene expression: implications on antibiotic resistance and tolerance in E. coli To be or not to be Synchronized Ribosome heterogeneity – A specific focus on 2’-O-ribose methylations 16:15 - 18:15 (2h) SESSION 5: HETEROGENEITY AS AN OPTIMUM 16:15 - 17:15 (1h) Heterogeneity in gene expression: implications on antibiotic resistance and tolerance in E. coli Imane el Meouche 17:15 - 17:45 (30min) To be or not to be Synchronized Marc Prudhomme 17:45 - 18:15 (30min) Ribosome heterogeneity – A specific focus on 2’-O-ribose methylations Jérôme Cavaillé	SESSION 6: TECHNOLOGICAL SOLUTIONS TO TAKE INTO ACCOUNT HETEROGENEITY IN BIOLOGICAL MEASUREMENTS Tackling tumor heterogeneity using droplet microfluidics technology New cryo-EM developments at METi platform to assess structural heterogenity of cells and molecules Coffee break LITC - Randomness to improve measurement precision: RIM 9:00 - 12:15 (3h15) SESSION 6: TECHNOLOGICAL SOLUTIONS TO TAKE INTO ACCOUNT HETEROGENEITY IN BIOLOGICAL MEASUREMENTS Auditorium CBI 9:00 - 10:00 (1h) Tackling tumor heterogeneity using droplet microfluidics technology Linas Mažutis 10:00 - 10:20 (20min) New cryo-EM developments at METi platform to assess structural heterogenity of cells and molecules MeTi 10:20 - 11:00 (40min) Coffee break 11:00 - 12:00 (1h) LITC - Randomness to improve measurement precision: RIM Thomas Mangeat

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